Review: metformin does not increase risk of lactic acidosis or increase lactate levels in type 2 diabetes
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منابع مشابه
Review: metformin does not increase fatal or nonfatal lactic acidosis or blood lactate levels in type 2 diabetes mellitus.
S t u d y s e l e c t i o n Clinical trials and cohort studies were selected if they included patients with type 2 diabetes, lasted ≥ 1 month, compared metformin alone or combined with other treatments with placebo or any other hypoglycemic therapy, and reported the number of patients and duration of treatment. D a t a e x t r a c t i o n Data were extracted on study methods and quality, partic...
متن کاملDoes metformin increase the risk of fatal or nonfatal lactic acidosis?
Practice Pointers The first-line treatments recommended for type 2 diabetes are lifestyle changes and metformin, which is a biguanide antihyperglycemic agent.2 Demonstrated benefits of metformin include lower cardiovascular mortality than other oral diabetes medications3 and a reduced risk of death or myocardial infarction in overweight patients with type 2 diabetes.4 However, because an earlie...
متن کاملAssociation between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes
PURPOSE Metformin can reduce diabetes-related complications and mortality. However, its use is limited because of potential lactic acidosis-associated adverse effects, particularly in renal impairment patients. We aimed to investigate the association of metformin use with lactic acidosis and hyperlactatemia in patients with type 2 diabetes. MATERIALS AND METHODS This was a cross-sectional stu...
متن کاملRisk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
BACKGROUND Metformin is an oral anti-hyperglycemic agent that has been shown to reduce total mortality compared to other anti-hyperglycemic agents, in the treatment of type 2 diabetes mellitus. Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, suc...
متن کاملReview: thiazolidinediones increase congestive heart failure but not cardiovascular deaths in prediabetes or type 2 diabetes.
M e t h o d s Data sources: MEDLINE, EMBASE/ Excerpta Medica, Database of Abstracts of Reviews of Effects, and Cochrane Library (1998 to March 2007); hand searches of professional association databases (European Society of Cardiology, American Heart Association, American College of Cardiology, and American Diabetes Association); and reference lists of relevant articles. Study selection and asse...
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ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2004
ISSN: 1356-5524
DOI: 10.1136/ebm.9.4.111